Pipeline Database & Screener

Over 1000 entries in Phase 2, 3 or NDA development of small and mid-cap biotech companies listed on AMEX/NASDAQ.Generally no OTC companies are listed unless the upcoming catalyst is a PDUFA event. LARGE cap companies are also NOT featured in the database

Company SCREENER also available to filter through financial and clinical data.

N.B. The short ratio is the number of shares sold short divided by the average daily volume, also known as the number of ”days to cover”.

Pipeline data are updated at the end of each trading day. Click on the date for the source of the catalyst. Financial data are updated each evening usually by 5pm EST.

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Showing 395 companies
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Price
Short ratio
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Price
Change
Market Cap
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Short Ratio
Updated
$38.65
+0.1  +0.26%
$1.52B
39,278,000
1.54
09/06/2016
Tap to view 6 drugs
Drug Indication Stage News
Annexin V-128 Apoptosis Phase 2 Phase 2 initiated September 2016
Annexin V-128 Rheumatoid arthritis and ankylosing spondylitis Phase 1/2 Ongoing
Apoptosis Necrosis Phase 2 Phase 2 initiated September 2016
Lutathera Inoperable progressive midgut NETs PDUFA PDUFA date under priority review December 28, 2016
Somakit-TATE Neuroendocrine tumor diagnosis Approved Approved June 1 2016
Somakit-TOC Neuroendocrine cancers MAA filed October 2015
$6.11
-0.18  -2.86%
$204.96M
33,545,000
6.30
09/26/2016
Tap to view 2 drugs
Drug Indication Stage News
ABO-101 Recessive dystrophic epidermolysis bullosa (RDEB) Phase 2 Phase 2 enrollment commenced September 2016.
ABO-102 Sanfilippo syndrome type A (MPS IIIA) Phase 1/2 Phase 1/2 dosing initiated May 2016. Continues to enrol as of August 2016
$2.90
+0.04  +1.72%
$26.28M
9,066,000
8.30
08/14/2016
Tap to view 1 drug
Drug Indication Stage News
Gencaro - GENETIC-AF trial Chronic Heart Failure Phase 2b Phase 2b interim analysis due 2Q 2017
$3.99
+0.03  +0.76%
$218.64M
54,796,000
13.82
08/05/2016
Tap to view 2 drugs
Drug Indication Stage News
ARB-1467 Hepatitis B (HBV) Phase 2 Phase 2 single dose data due 3Q 2016, multiple dose data due 4Q 2016
TKM-PLK1 Hepatocellular carcinoma (HCC) Phase 1/2 Phase 1/2 data released July 2016. Intends to explore partnership opportunities to enable further study
$34.30
-0.68  -1.94%
$3.91B
114,005,000
9.13
08/13/2016
Tap to view 3 drugs
Drug Indication Stage News
Pimavanserin Alzheimer’s disease agitation Phase 2 Phase 2 trial to be initiated 2H 2016
Pimavanserin Parkinson’s disease psychosis (PDP) Approved Approved April 29 2016
Pimavanserin Alzheimer’s disease psychosis Phase 2 Phase 2 top-line data due 4Q 2016
$8.34
-0.35  -4.03%
$1.14B
136,680,000
12.48
09/23/2016
Tap to view 3 drugs
Drug Indication Stage News
ACH-4471 Paroxysmal nocturnal hemoglobinuria (PNH) Phase 2 Phase 2 interim data due by end of 2016
Odalasvir (ACH-3102) and sofosbuvir Hepatitis C (HCV) Phase 2b Phase 2b trial to be initiated 3Q 2016
Odalasvir (ACH-3102), simeprevir and ALS-335 Hepatitis C (HCV) Phase 2a Phase 2a top-line updated data released September 23, 2016 at EASL.
$16.50
+0.84  +5.36%
$N/A
0
0.00
09/24/2016
Tap to view 3 drugs
Drug Indication Stage News
ACI-24 (anti-Abeta vaccine ) Alzheimer’s disease Phase 1/2 Phase 1/2 top-line data due 2H 2016. IPO September 23, 2016.
ACI-35 (anti-tau vaccine) Alzheimer’s disease Phase 1b Phase 2 trial to commence 2017. IPO September 23, 2016.
Crenezumab Alzheimer’s disease Phase 3 Phase 3 trial commenced 1Q 2016. Phase 2 trial did not meet co-primary endpoints. IPO September 23, 2016.
$22.99
-4.29  -15.73%
$1.06B
46,090,000
11.82
08/13/2016
Tap to view 3 drugs
Drug Indication Stage News
CVT-301 OFF episodes of Parkinson’s disease (PD) Phase 3 Phase 3 data due 1Q 2017
Dalfampridine Post stroke deficits Phase 3 Phase 3 data due 2H 2016
Tozadenant Parkinson’s disease (PD) Phase 3 To be acquired from Biotie Therapies Corp 2H 2016
$24.93
+0.07  +0.28%
$533.88M
21,415,000
12.80
08/31/2016
Tap to view 2 drugs
Drug Indication Stage News
A-101 Seborrheic keratosis (SK) Phase 3 Phase 3 data due 4Q 2016
A-101 Common warts (verruca vulgaris) Phase 2 Phase 2 data released August 18, 2016. Endpoints met.
$3.62
-0.06  -1.63%
$164.03M
45,312,000
13.60
09/17/2016
Tap to view 3 drugs
Drug Indication Stage News
ARX-04 (SAP302) Patients who presented to emergency departments with moderate-to-severe acute pain associated with trauma or injury Phase 3 Phase 3 data released August 15 2016
ARX-04 (SAP303) Moderate-to-severe acute pain following a surgical procedure NDA Filing Phase 3 data released September 15, 2016. NDA filing due 4Q 2016.
Zalviso Post-operative pain following open abdominal surgery and hip or knee replacement surgery Phase 3 CRL Jul 26 2014. Additional clinical trial required. NDA Filing due by end of 2016
$1.86
-0.03  -1.59%
$19.92M
10,712,000
0.27
09/14/2016
Tap to view 1 drug
Drug Indication Stage News
CaPre (TRIFECTA trial) Hypertriglyceridemia Phase 2 Phase 3 planned.
$7.13
+0.01  +0.14%
$504.70M
70,785,000
3.13
08/13/2016
Tap to view 6 drugs
Drug Indication Stage News
NY-ESO T-cell therapy Synovial sarcoma - cancer Phase 3 Phase 3 to be initiated mid 2017
NY-ESO T-cell therapy Ovarian cancer Phase 1/2 Further trials planned for 2H 2016
NY-ESO T-cell therapy Myxoid round cell liposarcoma (MRCLS) Phase 3 Clinical hold placed on pivotal study. Envisage initiation 4Q 2016 or 1Q 2017
NY-ESO T-cell therapy Myeloma Phase 1/2 Further trials planned for 1H 2017
NY-ESO T-cell therapy Non-small cell lung cancer (NSCLC) Phase 1/2 Phase 1/2 initiated November 2015. Data are due 2017
NY-ESO T-cell therapy Melanoma Phase 1/2 Further trials planned for 2017
$4.59
-0.06  -1.29%
$126.51M
27,562,000
21.04
08/30/2016
Tap to view 3 drugs
Drug Indication Stage News
MDX (Metadoxine Extended Release (MG01CI)) Adult ADHD Phase 3 Phase 3 enrollment to be completed by the end of 2016. Data due 1Q 2017
MDX (Metadoxine Extended Release (MG01CI)) Pediatric ADHD Phase 2 Phase 2b data released March 2015. Secondary cognitive measures did not produce statistically significant results. Enrollment to commence in registration trials 4Q 2016.
MDX (Metadoxine Extended Release (MG01CI)) Fragile X Syndrome Phase 2 Phase 2 trial did not meet endpoints - June 2015. In discussions with FDA regarding Phase 3 trial
$7.40
+0.05  +0.68%
$95.36M
12,886,000
1.38
08/02/2016
Tap to view 1 drug
Drug Indication Stage News
RI-002 Primary Immune Deficiency Diseases CRL CRL issued July 29 2016. Third-party manufacturing issues cited.
$3.45
+0.06  +1.77%
$72.06M
20,886,000
0.98
08/14/2016
Tap to view 3 drugs
Drug Indication Stage News
APC-1000 Asthma/COPD Phase 2 Phase 3 planned
APC-3000 Allergic Rhinitis Phase 2 Phase 3 planned
Epinephrine Pre-filled Syringe (PFS) Emergency treatment of anaphylaxis. CRL CRL issued March 27 2015. NDA resubmitted. CRL issued again June 6, 2016. Intends to submit more data 2H 2016
$17.65
+0.3  +1.73%
$387.05M
21,929,000
15.09
08/05/2016
Tap to view 3 drugs
Drug Indication Stage News
ADS-5102 Multiple sclerosis (MS) Phase 2 Phase 2 data released early June 2016
ADS-5102 - EASE LID trial Levodopa-Induced Dyskinesia NDA Filing Phase 3 data released December 2015. NDA filing due 2016
Namzaric Moderate to severe dementia of the Alzheimer’s type. Approved Approved Dec 24 2014
$13.24
-1.3  -8.94%
$857.34M
64,754,000
16.90
08/14/2016
Tap to view 4 drugs
Drug Indication Stage News
CRS-207 Mesothelioma - cancer Phase 3 Development path to be announced 2H 2016
CRS-207 and GVAX Pancreas - ECLIPSE trial Pancreatic cancer Phase 2b Phase 2b primary endpoint not met - May 2016
CRS-207 and GVAX Pancreas and nivolumab - STELLAR trial Pancreatic cancer Phase 2b Phase 2b interim data to be released 2H 2016
Epacadostat and CRS-207 - SEASCAPE Ovarian cancer Phase 1/2 Phase 1/2 dosing initiated March 2016
$4.02
-0.18  -4.29%
$166.22M
41,348,000
1.98
07/25/2016
Tap to view 1 drug
$10.54
-0.26  -2.41%
$419.96M
39,844,000
4.94
08/14/2016
Tap to view 6 drugs
Drug Indication Stage News
ADXS-HER2 HER2-driven malignancies - cancer Phase 1b Complete enrollment of Phase 1b dose-escalation study 1H 2016
ADXS-PSA and Keytruda Castrate-resistant prostate cancer Phase 1/2 Completed the first two dose-escalation cohorts and launched the third dose-escalation cohort in April 2016
Axalimogene filolisbac Anal cancer (FAWCETT) Phase 2 Phase 2 initiated June 2016
Axalimogene filolisbac - AIM2CERV Trial High-risk, locally advanced cervical cancer Phase 3 Phase 3 to commence 3Q 2016
Axalimogene filolisbac - GOG 0265 study Cervical cancer Phase 2 Phase 2 preliminary data released June 2016 at ASCO. Stage 2 enrollment to commence 3Q 2016
Axalimogene filolisbac + durvalumab Recurrent or refractory HPV-associated cervical cancer and head & neck cancer Phase 1/2 Phase 1/2 second dose-escalation cohort completed July 2016
$2.65
-0.1  -3.64%
$78.21M
29,514,000
16.26
09/11/2016
Tap to view 1 drug
Drug Indication Stage News
Lomitapide Homozygous familial hypercholesterolemia (HoFH) Approved Early approval Dec 24 2012
$39.36
+0.28  +0.74%
$1.10B
27,892,000
11.74
09/14/2016
Tap to view 2 drugs
Drug Indication Stage News
Rhopressa Glaucoma NDA Filing Announced NDA Filing September 6, 2016
Roclatan - Mercury trials Glaucoma Phase 3 Phase 3 Mercury 1 data released September 14, 2016. Primary endpoint met. Mercury 2 trial data due 2Q 2017.
$3.42
-0.04  -1.16%
$33.99M
9,939,000
7.41
08/13/2016
Tap to view 2 drugs
Drug Indication Stage News
Macimorelin Acetate - Macrilen Adult Growth Deficiency Phase 3 CRL Nov 5 2014. Initiated Phase 3 trial in November 2015, to be completed 2016
Zoptrex Endometrial cancer Phase 3 Phase 3 trial to be completed 2016
$2.82
-0.12  -4.08%
$94.43M
33,487,000
7.63
08/14/2016
Tap to view 2 drugs
Drug Indication Stage News
AFM13 Hodgkin Lymphoma - Cancer Phase 1b Phase 1b update due end of 2016 or early 2017
AFM13 Hodgkin Lymphoma - Cancer Phase 2 Phase 2a monotherapy trial is currently being modified - August 2016
$7.03
+0.13  +1.88%
$610.99M
86,912,000
5.75
08/03/2016
Tap to view 1 drug
Drug Indication Stage News
INCAGN1876 Solid tumors - cancer Phase 1/2 Phase 1/2 trial commenced June 2016
$52.70
-0.33  -0.62%
$2.01B
38,046,000
10.91
09/07/2016
Tap to view 5 drugs
Drug Indication Stage News
AG-120 Frontline Acute myeloid leukemia (AML) harboring an IDH1 mutation - cancer Phase 3 Phase 3 to be initiated 1H 2017
AG-120 IDH1 mutant positive cholangiocarcinoma - cancer Phase 2 Phase 2 to be initiated 2H 2016
AG-221 Advanced hematologic malignancies with an IDH2 mutation NDA Filing NDA filing due by the end of 2016
AG-221 - IDHENTIFY Refractory Acute myeloid leukemia (AML) - cancer Phase 3 Global Phase 3 study for AG-221 initiated October 2015. Continue to enrol through 2016
AG-348 Pyruvate kinase deficiency Phase 2 Phase 2 first data released at EHA meeting June 2016
$7.21
-0.04  -0.56%
$207.30M
28,752,000
5.69
08/14/2016
Tap to view 1 drug
Drug Indication Stage News
Twirla Contraceptive patch Phase 3 CRL issued 2013. Phase 3 to be completed 4Q 2016.
$8.91
-0.05  -0.57%
$160.85M
18,053,000
4.93
09/13/2016
Tap to view 2 drugs
Drug Indication Stage News
AAV Gene Therapy Achromatopsia Phase 1/2 Phase 1/2 currently enrolling at slower rate than planned
rAAV-hRS1 X-linked retinoschisis (XLRS) Phase 1/2 Phase 1/2 currently enrolling at slower rate than planned
$15.91
-0.66  -3.98%
$672.26M
42,254,000
13.43
09/20/2016
Tap to view 1 drug
Drug Indication Stage News
AR101 Peanut Allergy Phase 3 Phase 3 initiated January 2016. Top-line data due 4Q 2017.
$4.30
-0.04  -0.92%
$114.72M
26,679,000
3.88
09/01/2016
Tap to view 2 drugs
Drug Indication Stage News
Plazomicin - CARE Serious bacterial infections due to carbapenem-resistant Enterobacteriaceae (CRE) Phase 3 Phase 3 topline data due 1Q 2017
Plazomicin - EPIC trial Complicated urinary tract infections (cUTI) Phase 3 Phase 3 top-line results due 1Q 2017
$8.98
-0.16  -1.75%
$164.33M
18,300,000
11.83
08/14/2016
Tap to view 2 drugs
Drug Indication Stage News
Vadadustat - INNO2VATE Anemia related to chronic kidney disease who are undergoing dialysis (DD-CKD) Phase 3 Phase 3 initiated August 2016. Enrollment to be completed by early 2018
Vadadustat - PRO2TECT Non-dialysis patients with anemia related to CKD (NDD-CKD) Phase 3 Phase 3 initiated January 2016. NDA to be filed 2019 assuming postive data
$32.76
-1.21  -3.56%
$1.64B
50,184,000
14.06
09/17/2016
Tap to view 2 drugs
Drug Indication Stage News
ALD403 Chronic Migraine Phase 2b Phase 2b data released March 2016 met primary and secondary endpoints. 24 week data released July 2016.
ALD403 - PROMISE 1 Frequent episodic migraine Phase 3 Phase 3 topline data due 1H 2017. PROMISE 2 trial to be initiated 2H 2016
$7.70
+0.25  +3.36%
$48.09M
6,245,000
1.10
08/13/2016
Tap to view 3 drugs
Drug Indication Stage News
NS2 Allergic conjunctivitis Phase 2 Phase 2/3 trial to begin 2H 2016. Data due 2H 2017
NS2 Noninfectious anterior uveitis Phase 2 Phase 2/3 to begin 2H 2016. Data expected mid-2018
NS2 Sjögren-Larsson Syndrome (SLS) Phase 2 Phase 2 data released August 2016
$1.58
-0.04  -2.48%
$72.30M
45,759,000
1.32
09/11/2016
Tap to view 1 drug
Drug Indication Stage News
Iluvien Diabetic macular edema Approved CRL Nov 2011. Second CRL Oct 17 2013. Approved Sept 26 2014
$48.58
-1  -2.02%
$7.36B
151,556,000
7.16
08/14/2016
Tap to view 6 drugs
Drug Indication Stage News
ALKS 3831 - ENLIGHTEN-1 and ENLIGHTEN-2 Schizophrenia Phase 3 Pivotal trials initiated December 2015 and February 2016
ALKS 5461 Major depressive disorder Phase 2 Phase 3 data from first two trials did not meet their endpoints. FORWARD-5 data, the third of three trials, due by end of 2016
ALKS 6428 Opioid dependence Phase 3 Phase 3 initated September 2015
ALKS 8700 Multiple sclerosis (MS) Phase 3 Phase 3 trial to be initiated mid-2016 with data due 2018
Aristada Schizophrenia sNDA Filing Approved October 5 2015. sNDA filed for 2-month option August 8 2016
Aristada Schizophrenia Approved Approved October 5 2015. sNDA filing due 2H 2016
$76.00
+0.43  +0.56%
$6.52B
85,724,000
13.73
09/26/2016
Tap to view 7 drugs
Drug Indication Stage News
ALN-CC5 Paroxysmal nocturnal hemoglobinuria (PNH) Phase 1/2 Phase 1/2 initial data released June 11 2016 with Phase 2 trial to be initiated towards the end of 2016
ALN-GO1 Primary Hyperoxaluria Type 1 (PH1) Phase 1/2 Phase 1/2 initiated March 2016. Initial data released September 2016.
ALN-HBV Chronic hepatitis B virus (HBV) Phase 1/2 Phase 1/2 trial initiated July 2016. Data are due mid 2017
ALN-TTRsc02 ATTR amyloidosis Phase 1 Phase 3 to be initiated 2017 assuming positive Phase 1 initial data due end of 2016
Fitusiran Hemophilia Phase 3 Phase 3 program to be initiated early 2017
Patisiran APOLLO Familial Amyloidotic Polyneuropathy (FAP) in Patients with ATTR Phase 3 Phase 3 data due mid 2017
Revusiran ENDEAVOUR ATTR in patients with familial amyloidotic cardiomyopathy (FAC) Phase 3 Phase 3 data due early 2018
$24.07
-0.17  -0.7%
$822.09M
34,154,000
5.88
08/13/2016
Tap to view 2 drugs
Drug Indication Stage News
Feraheme Adults with iron deficiency anemia (IDA) Phase 3 Phase 3 dosing commenced March 2016. sNDA in late 2017.
Makena - single-dose vial Reduce the risk of preterm birth in women with a singleton pregnancy Approved Approved February 23 2016
$3.12
+0.18  +6.12%
$575.80M
184,551,000
2.59
09/12/2016
Tap to view 1 drug
Drug Indication Stage News
Vascepa REDUCE-IT outcomes trial High Triglycerides With Mixed Dyslipidemia Interim analysis announced September 12, 2016 - trial to proceed.Second interim analysis due mid 2017. Final data due 2018
$45.82
-1.11  -2.34%
$677.08M
14,777,000
6.41
08/14/2016
Tap to view 2 drugs
$3.16
-0.03  -0.94%
$130.91M
41,427,000
11.08
08/13/2016
Tap to view 3 drugs
Drug Indication Stage News
Blisibimod IgA nephropathy Phase 2 Phase 2 primary endpoint not met
Blisibimod Lupus Phase 3 Missed primary endpoints in Phase 2b trial Jun 2012. Phase 3 final data due early 4Q 2016
Sollpura (liprotamase) Cystic fibrosis who suffer from exocrine pancreatic insufficiency Phase 3 Phase 3 initiated October 2015. Top-line data due 4Q 2016
$3.22
-0.35  -9.81%
$12.48M
3,876,000
0.48
07/25/2016
Tap to view 1 drug
$0.34
-0.01  -2.32%
$22.67M
66,350,000
2.77
08/05/2016
Tap to view 2 drugs
Drug Indication Stage News
RayVa Secondary Raynaud’s Phenomenon Phase 2b Phase 2b planned - seeking partnership
Vitaros Erectile dysfunction NDA Filing NDA to be resubmitted at earliest late 4Q 2016
$14.38
-0.39  -2.64%
$247.51M
17,212,000
11.61
09/06/2016
Tap to view 3 drugs
Drug Indication Stage News
AQX-1125 FLAGSHIP Chronic obstructive pulmonary disease (COPD) Phase 2 Phase 2 trail failed - July 2015
AQX-1125 KINSHIP Atopic dermatitis (AD) Phase 2 Phase 2 failed to demonstrate efficacy November 2015
AQX-1125 LEADERSHIP Bladder pain syndrome/interstitial cystitis (BPS/IC). Phase 3 Phase 2 trial did not meet endpoints - June 2015 but postive secondary endpoint data - August 2015. Phase 3 trial commenced September 2016. Top-line data due 4Q 2017
$6.67
+0.17  +2.61%
$98.59M
14,781,000
0.17
09/22/2016
Tap to view 1 drug
Drug Indication Stage News
Pulmaquin - ORBIT-3 and ORBIT-4 Non-cystic fibrosis bronchiectasis (non-CF BE). Phase 3 Phase 3 data due 4Q 2016.
$12.27
-0.04  -0.32%
$579.76M
47,250,000
6.16
08/13/2016
Tap to view 3 drugs
Drug Indication Stage News
RDX227675 Hyperkalemia Phase 3 Onset-of-action and Phase 3 trials to be initiated 4Q 2016 with data due 1H 2017 from onset-of-action trial.
Tenapanor Hyperphosphatemia in end-stage renal disease (ESRD) patients Phase 3 Phase 3 data due 1Q 2017
Tenapanor Constipation-predominant irritable bowel syndrome (IBS-C) Phase 3 Phase 3 trial initiated October 2015. Second trial initiated December 2015. Data from first trial due mid 2017, with data from second trial due later that year
$4.63
-0.21  -4.34%
$190.74M
41,196,000
5.19
08/14/2016
Tap to view 4 drugs
Drug Indication Stage News
AGS-003 Non-Small Cell Lung Cancer Phase 2 Phase 2 initiated 1Q 2016
AGS-003 Early stage renal cell carcinoma (RCC) - cancer Phase 2 Phase 2 initial data due 4Q 2016
AGS-003 ADAPT Trial Metastatic renal cell carcinoma (mRCC) Phase 3 Phase 3 overall survival analysis due 1H 2017
AGS-004 HIV Phase 2 Phase 2 second stage commenced dosing July 2016
$13.96
+0.44  +3.25%
$2.69B
192,713,000
6.15
09/11/2016
Tap to view 6 drugs
Drug Indication Stage News
AP32788 Non-small cell lung cancer (NSCLC) Phase 1/2 Phase 1/2 enrolling as of July 2016
Brigatinib ALK+ non-small cell lung cancer (NSCLC) - front line Phase 3 Phase 3 trial initiated April 2016. Enrolment to be completed 2018
Brigatinib - ALTA trial Anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) NDA Filing Announced August 30, 2016 completion of NDA rolling submission. Priority review requested
Iclusig (ponatinib) Cancer - third line chronic-phase CML (CP-CML) Phase 2 Phase 2 dose ranging trial initiated August 2015. Preliminary data due end of 2016
Iclusig (ponatinib) Cancer - second line chronic-phase CML (CP-CML) Phase 3 Phase 3 enrolment to be completed in 2018
Oral ponatinib Cancer - chronic myeloid leukemia, acute lymphoblastic leukemia Approved PDUFA March 27 2013. Early approval Dec 14 2012 under priority review
$5.05
-0.27  -5.08%
$329.47M
65,241,000
3.76
09/15/2016
Tap to view 1 drug
Drug Indication Stage News
YOSPRALA (PA32540/PA8140) Secondary prevention of cardiovascular disease in patients at risk for aspirin-induced gastric ulcers Approved Approval announced September 15, 2016.
$1.73
-0.01  -0.57%
$420.83M
243,256,000
12.62
08/13/2016
Tap to view 4 drugs
Drug Indication Stage News
APD334 Ulcerative colitis Phase 2 Phase 2 data due 4Q 2016
APD371 Pain associated with Crohn’s disease Phase 2 Phase 2 to be initiated 2017
Lorcaserin Smoking cessation Phase 2 Phase 2 initiated March 2014. Data released Nov 2014
Ralinepag Pulmonary Arterial Hypertension Phase 2 Phase 2 data due mid 2017
$1.75
+0.1  +6.06%
$124.44M
71,106,000
1.30
08/04/2016
Tap to view 2 drugs
Drug Indication Stage News
ARQ 087 intrahepatic cholangiocarcinoma (iCCA) Phase 1/2 Phase 1/2 preliminary data released June 2016.
Tivantinib (ARQ 197) METIV-HCC trial Previously treated Inoperable Hepatocellular Carcinoma cancer Phase 3 Phase 3 SPA agreed upon. Dosage reduced following recommendation from DMC. Final analysis late 2016 or early 2017
$6.61
+2.96  +81.09%
$958.60M
145,022,000
5.67
09/26/2016
Tap to view 7 drugs
Drug Indication Stage News
ARRY 797 LMNA A/C-related dilated cardiomyopathy (DCM) Phase 2 Phase 2 data presented at the European Society of Cardiology on August 30, 2016
ARRY-520 (Filanesib) Refractory Multiple Myeloma Cancer Phase 2 Phase 2 interim data due 2016 but no plans to advance program
Binimetinib - COLUMBUS BRAF mutant melanoma cancer Phase 3 Phase 3 data released September 26, 2016 met primary endpoint. NDA filing due 2017. Data from Part 2 portion of trial due mid-2017.
Binimetinib - MILO Recurrent low-grade serous ovarian cancer (LGSOC) Phase 3 Phase 3 trial discontinued April 2016
Binimetinib (NEMO) NRAS melanoma - cancer PDUFA PDUFA date June 30, 2017
Encorafenib and cetuximab - BEACON CRC BRAF-Mutant Colorectal Cancer Phase 3 Phase 3 initiated June 2016. SPA announced September 2016. Enrollment to be completed 2018.
Selumetinib - SELECT-1 Differentiated thyroid cancer Phase 3 Phase 3 trial did not meet its primary endpoint - August 2016
$7.04
-0.18  -2.5%
$427.68M
60,750,000
9.62
09/07/2016
Tap to view 3 drugs
Drug Indication Stage News
ARC-520 injection in combination with entecavir or tenofovir Chronic Hepititis B (HBV) Phase 2 Partial clinical hold placed by FDA in early Jan 2015. Phase 2 trial to proceed with lower doses than initially proposed. Dosing commenced January 2016
ARC-521 Chronic Hepititis B (HBV) Phase 1/2 Phase 1/2 dosing initiated September 2016. First readout potentially due 1Q 2017
ARC-AAT Alpha-1 antitrypsin deficiency (AATD) Phase 2 Phase 2 initiated September 2016
$8.14
+0.13  +1.62%
$140.21M
17,225,000
8.28
07/25/2016
Tap to view 1 drug
Drug Indication Stage News
VEN 307 (diltiazem cream) Anal fissures Phase 3 Phase 3 data from second trial did not meet primary endpoint - Feb 2014. Will not pursue future development
$19.87
+0.24  +1.22%
$500.58M
25,193,000
12.55
08/14/2016
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Drug Indication Stage News
TransCon Growth hormone deficiency in children Phase 3 Phase 3 initiated August 2016.
$4.54
-0.11  -2.37%
$206.20M
45,418,000
9.99
09/14/2016
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Drug Indication Stage News
AST-OPC1 SCiSTAR Cervical spinal cord injury Phase 1/2 Phase 1/2 six-month data due January 2017. Interim data presented September 14, 2016.
AST-VAC1 Acute myeloid leukemia (AML) Phase 2 Phase 3 planned for late 2017
AST-VAC2 Non-small cell lung cancer (NSCLC) Phase 1/2 Phase 1/2 trial to be initiated 2017
$1.96
-0.06  -2.97%
$166.56M
84,982,000
22.97
07/25/2016
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Drug Indication Stage News
Multistem Ischemic stroke Phase 2 Phase 2 data released mid April 2015. Endpoints not met.
Multistem Acute myocardial infarction Phase 2 Phase 2 enrolment but reported May 2016 that enrolment is slower than expected
$2.00
+0.21  +11.73%
$95.43M
47,717,000
6.16
09/21/2016
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Drug Indication Stage News
Actimab-A Acute Myeloid Leukemia (AML) Phase 2 Phase 2 to be initiated 2H 2016. Update to be provided September 27, 2016.
Iomab-B Hematopoietic Stem Cells Transplantation Phase 3 Phase 3 initiated June 2016. Data due 1H 2018
$2.07
-0.11  -5.05%
$5.46M
2,637,000
1.17
07/25/2016
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Drug Indication Stage News
Fulvestrant Cuctal carcinoma in situ(DCIS) - invasive breast cancer Phase 2 Phase 2 initiated March 2016
$19.94
-0.18  -0.89%
$574.49M
28,811,000
19.01
08/14/2016
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Drug Indication Stage News
CMV-CTL Refractory CMV Chorioretinitis or Meningoencephalitis Phase 2 Phase 2 data released at ASH 2015. Expects to meet with FDA during 4Q 2016 to discuss further development
EBV-CTL Epstein-Barr virus (EBV-PTLD) Phase 2 Pivotal trials to be initiated by the end of 2016
EBV-CTL Nasopharyngeal carcinoma (NPC) Phase 2 Phase 2 trial to be initiated 2017
PINTA 745 Protein-energy wasting Phase 2 Phase 2 endpoint not met December 2015
$1.65
-0.01  -0.6%
$255.85M
155,058,000
3.35
09/22/2016
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Drug Indication Stage News
OTREXUP Rheumatoid arthritis (RA) Approved Approved Oct 14 2013
VIBEX QuickShot Testosterone deficiency NDA Filing NDA to be filed 4Q 2016.
$2.39
-0.01  -0.42%
$84.33M
35,286,000
0.48
08/16/2016
Tap to view 1 drug
$0.89
-0.02  -1.67%
$67.14M
75,859,000
5.38
09/12/2016
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Drug Indication Stage News
Ficlatuzumab EGFR-mutated Non-small cell lung cancer (NSCLC) Phase 2 Announced September 12, 2016 that its Phase 2 trial has been discontinued
TIVO-3 - tivozanib Third line treatment of patients with renal cell cancer Phase 3 CRL June 10 2013. Phase 3 dosing commenced May 2016. Data due 1Q 2018
$1.86
+0.2  +12.05%
$71.87M
38,640,000
2.33
08/06/2016
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Drug Indication Stage News
BTA074 5% topical gel Condyloma Phase 2 Phase 2 top-line data due 2H 2017
BTA585 Respiratory syncytial virus (RSV) Phase 2a Phase 2a initiated April 2016. Enrolment halted May 2016 due to safety issues
Laninamivir Octanoate - IGLOO Adults with symptomatic influenza A or B infection Phase 2 Phase 2 initiated Jun 2013. Topline data did not meet the primary endpoint - July 2014
Vapendavir - SPIRITUS trial Human rhinovirus (HRV) Phase 2b Phase 2b top-line data due 2H 2016
$3.15
+0.04  +1.29%
$112.49M
35,710,000
4.06
07/25/2016
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Drug Indication Stage News
ANAVEX 2-73 Mild to moderate Alzheimer’s disease Phase 2a Phase 2a interim data released January 2016. Trial is ongoing. Additional Phase 2/3 trial planned
$40.12
-1.31  -3.16%
$923.28M
23,013,000
2.94
08/14/2016
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Drug Indication Stage News
AVXS-101 Spinal muscular atrophy (SMA) Type 1 Phase 1 Phase 1 ongoing. Data due 1Q 2017. Pivotal trial to be initiated 1H 2017
$14.71
-0.57  -3.73%
$1.46B
99,161,000
28.59
08/16/2016
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Drug Indication Stage News
Intepirdine - HEADWAY-DLB Dementia with Lewy bodies (DLB) Phase 2b Phase 2b data due 2017
Intepirdine - MINDSET Alzheimer’s disease Phase 3 Phase 3 initiated October 2015. Data are due 2017
Nelotanserin DLB patients experiencing REM Behavior Disorder (RBD) Phase 2 Phase 2 data due 2017
Nelotanserin Visual hallucinations in subjects with Lewy body dementia Phase 2 Phase 2 data due 2H 2016
$7.57
-0.04  -0.53%
$144.96M
19,149,000
14.59
08/14/2016
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Drug Indication Stage News
AXS-02 Complex regional pain syndrome (CRPS) Phase 3 Initiated July 2015. Expect to complete trial by end of 2017
AXS-02 Chronic Low Back Pain Associated with Modic Changes Phase 3 Phase 3 to be initiated 4Q 2016 or 1Q 2017
AXS-02 COAST-1 Knee Osteoarthritis Associated with Bone Marrow Lesions Phase 3 Phase 3 commenced March 2016
AXS-05 Agitation in patients with Alzheimer’s disease (AD) Phase 2/3 Phase 2/3 planned
AXS-05 STRIDE-1 Treatment resistant depression Phase 3 Phase 3 initiated March 2016
$2.43
-0.01  -0.41%
$45.33M
18,654,000
10.42
08/06/2016
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Drug Indication Stage News
NurOwn Amytrophic lateral sclerosis (ALS) Phase 2 Phase 2 data released July 2016. Pivotal trial planned
$4.71
+0  +0%
$347.13M
73,700,000
4.98
08/14/2016
Tap to view 3 drugs
Drug Indication Stage News
BCX4161 - OPuS-2 Hereditary angioedema Phase 2b Phase 2b data released February 2016 - primary endpoint not met
BCX7353 - APeX-1 Reduce or eliminate attacks in HAE patients Phase 2 Phase 2 screening has commenced - August 2016
Peramivir - Study 303 INFLUENZA ACUTE Approved Approved Dec 22 2014
$2.72
+0.02  +0.74%
$145.90M
53,639,000
12.39
08/05/2016
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Drug Indication Stage News
BEMA Buprenorphine Pain Approved Approved October 26 2015
BEMA Buprenorphine/Naloxone (BNX) - BUNAVAIL Opioid dependence Approved Approved June 7 2014
Clonidine gel Painful diabetic neuropathy (PDN) Phase 2b Phase 3 trial failed to meet primary endpoint late March 2015. New trial initiated late 2015. Data due from Phase 2b trial 4Q 2016
$29.50
-0.99  -3.25%
$970.64M
32,903,000
15.24
08/06/2016
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Drug Indication Stage News
BGB-3111 B-cell lymphoid malignancies Phase 1b Phase 1b enrolling
$0.44
-0.01  -1.25%
$28.51M
64,148,000
0.60
07/25/2016
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Drug Indication Stage News
BIOD-531 Type 2 diabetes Phase 2b Phase 2b initiated mid May 2015. Partial clinical hold lifted October 2015
$19.35
-1.22  -5.93%
$523.38M
27,048,000
9.18
08/13/2016
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Drug Indication Stage News
BPX-401 Hematological cancers that express the CD19 antigen Phase 1/2 Phase 1/2 planned 2H 2016
BPX-501 Adjunct T-cell therapy administered after allogeneic HSCT - (hematopoietic stem cell transplantation) - cancer Phase 1/2 Phase 1/2 interim data presented April 2016
BPX-601 Pancreatic cancer Phase 1/2 Phase 1/2 planned
BPX-701 PRAME (preferentially-expressed antigen in melanoma) -expressing melanoma, sarcomas and neuroblastoma cancer Phase 1/2 Phase 1/2 planned
$1.45
-0.04  -2.68%
$21.17M
14,599,000
1.88
08/14/2016
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Drug Indication Stage News
INOpulse delivery device Pulmonary Hypertension associated with Idiopathic Pulmonary Fibrosis (PH-IPF) Phase 2 Phase 2 initiated May 2016
INOpulse delivery device Pulmonary Arterial Hypertension (PAH) Phase 3 Phase 3 commenced enrollment June 2016
INOpulse delivery device Pulmonary Hypertension associated with COPD (PH-COPD) Phase 2 Phase 2 to be initiated 3Q 2016. Data due by end of 2016
$1.23
-0.05  -3.91%
$69.40M
56,423,000
0.63
09/20/2016
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Drug Indication Stage News
BL-7010 Gluten sensitivity Efficacy study to be initiated later in 2016
BL-8040 Consolidation treatment for AML cancer patients Phase 2b Phase 2b initiated August 2015. Enrollment continues as of August 2016
BL-8040 Mobilization and collection of bone marrow stem cells Phase 2 Phase 2 trial initiated March 2016. Partial data due by end of 2016 with topline data due by the end of 2017
BL-8040 Acute myeloid leukemia (AML) cancer relapsed and refractory Phase 2 Phase 2 data released March 2016. Full set of data presented September 8, 2016
BL-8040 in combination with KEYTRUDA Pancreatic cancer Phase 2 Phase 2 initiated September 2016.
$71.27
-0.41  -0.57%
$2.65B
37,169,000
9.11
09/08/2016
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Drug Indication Stage News
Lenti-D Childhood cerebral adrenoleukodystrophy (CCALD) Phase 2/3 Phase 2/3 trial initiated October 2013. Interim data released at AAN Conference April 20, 2016.
LentiGlobin β-Thalassemia Phase 1/2 Update expected at ASH December 2016
LentiGlobin - HGB-206 Sickle disease Phase 1/2 Update expected at ASH December 2016
LentiGlobin - HGB-207 non-β0/β0 transfusion-dependent thalassemia (TDT) Phase 3 Phase 3 trial initiated September, 2016
$95.87
-1.53  -1.57%
$15.67B
163,465,000
3.64
09/06/2016
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Drug Indication Stage News
BMN 270 Hemophilia A Phase 1/2 Phase 1/2 interim data released July 2016. Phase 2b to be initiated mid 2017
Cerliponase alfa Batten Disease PDUFA PDUFA date extended by three months to April 27 2017
Kyndrisa Duchenne Muscular Dystrophy (DMD) CRL CRL issued January 14 2016
PEG-PAL Phenylketonuria (PKU) BLA Filing Phase 3 data released March 2016. Primary endpoint hit. Key secondary endpoint missed. NDA (BLA) filing to be filed 4Q 2016 or 1Q 2017
Reveglucosidase alfa (BMN 701) Pompe Disease Phase 2 Program terminated June 2016
Vimizim (GALNS) (MPS IVA) Morquio A Syndrome Approved Approved Feb 14 2014
Vosoritide Achondroplasia Phase 2 Phase 2 data released April 2016. Phase 3 trial to be initiated end of 2016
$1.41
+0.02  +1.45%
$10.33M
7,326,000
0.37
07/25/2016
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Drug Indication Stage News
TT-034 Hepatitis C Phase 1/2 Announced late February 2016 plans to discontinue development
$0.63
-0.08  -11.27%
$19.64M
31,175,000
0.64
08/25/2016
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Drug Indication Stage News
BPX-01 Acne Phase 2b Phase 2b to be initiated August 2016. Data due 1H 2017
BPX-03 Moderate to severe periodic breast pain associated with FBC (fibrocystic breast condition) and cyclic mastalgia Phase 3 Phase 3 to be initiated in 2017
$45.39
+0.13  +0.28%
$318.27M
7,012,000
4.70
08/13/2016
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Drug Indication Stage News
XIAFLEX Plantar fibromatosis Phase 2 Phase 2 to commence 4Q 2016
XIAFLEX Human lipomas Phase 2 Phase 2 topline data released June 2016 - endpoints met
XIAFLEX Edematous fibrosclerotic panniculopathy (“cellulite”) Phase 2b Phase 2b initiated February 2016 by partner Endo
XIAFLEX Adhesive Capsulitis (“Frozen Shoulder syndrome”) Phase 2b Phase 2b trial did not meet endpoint. Additional trial to commence in 3Q 2016
$3.97
+0.17  +4.47%
$403.62M
101,667,000
29.68
08/15/2016
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Drug Indication Stage News
AST-VAC1 Maintenance of relapse-free-survival in acute myeloid leukemia (AML) Phase 3 Phase 3 planned
OpRegen Dry age-related macular degeneration (AMD) Phase 1/2 Phase 2 second cohort underway. Third cohort to be initiated by the end of 2016, pending positive data.
$3.68
+0  +0%
$12.43M
3,377,000
24.31
09/22/2016
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$3.15
+0.15  +5%
$61.39M
19,489,000
6.39
08/05/2016
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Drug Indication Stage News
CB-839 + nivolumab Phase 1/2 Phase 1/2 enrolment commenced August 2016
$2.60
-0.03  -1.14%
$36.98M
14,224,000
4.08
08/27/2016
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Drug Indication Stage News
CF101 Glaucoma Phase 2 Phase 2 failed to meet endpoint - July 2016
CF101 Rheumatoid arthritis Phase 3 Phase 3 planned. Protocol to be submitted 1Q 2017.
CF101 Psoriasis Phase 2/3 Phase 2/3 trial did not meet primary endpoint late March 2015. Meeting to discuss planned Phase 3 trial set for 3Q 2016.
CF101 Non-alcoholic steatohepatitis (NASH) Phase 2 Phase 2 planned. Protocol to be filed 2H 2016
CF102 Cancer - advanced liver cancer second line Phase 2 Phase 2 enrolment to be completed 2H 2016
$3.29
-0.22  -6.27%
$59.07M
17,954,000
2.74
09/07/2016
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Drug Indication Stage News
CAP-1002 ALLSTAR Myocardial infarction (heart attack) Phase 2 Phase 2 enrolling. 6 month data due 1Q 2017
CAP-1002 HOPE-Duchenne Duchenne Muscular Dystrophy (DMD) Phase 1/2 Phase 1/2 enrollment completed September 2016 with data due 1Q 2017
Cenderitide Ambulatory heart failure Phase 2 Phase 2 completed. Waiting on data from additional study to determine future
$7.75
+0.42  +5.73%
$211.44M
27,282,000
3.38
09/15/2016
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$1.59
+0.19  +13.57%
$215.14M
135,310,000
11.86
08/15/2016
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Drug Indication Stage News
ONT-380 + Herceptin and Xeloda HER2+ Metastatic Breast Cancer (MBC) Phase 2 Phase 2 combination trial initiated February 2016. Continues to enroll as of August 2016
ONT-380 and T-DM1 HER2+ Metastatic Breast Cancer (MBC) Phase 1b Phase 1b updated data released at ASCO 2016. Further data due by end of 2016
$1.17
-0.03  -1.96%
$57.70M
49,457,000
1.60
07/25/2016
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Drug Indication Stage News
ENMD-2076 Cancer - Advanced/Metastatic Soft Tissue Sarcoma Phase 2 Phase 2 initiated Jan 2013. Ongoing as of Nov 2015
ENMD-2076 Cancer - triple-negative breast cancer Phase 2 Phase 2 initiated Jul 2012. Ongoing as of Nov 2015
ENMD-2076 Cancer - fibrolamellar carcinoma (FLC). Phase 2 Phase 2 initiated October 2015
$4.64
+0.28  +6.42%
$71.37M
15,381,000
6.31
08/13/2016
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Drug Indication Stage News
CAT-1004 Duchenne muscular dystrophy (DMD) Phase 2 Phase 2 data due late 2016
CAT-2054 Hypercholesterolemia Phase 2a Phase 2a did not meet primary endpoint - June 2016
$1.94
-0.01  -0.51%
$45.49M
23,447,000
2.75
08/15/2016
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Drug Indication Stage News
Arhalofenate Gout Phase 3 Phase 3 planned - partner required
MBX-8025 Primary biliary cholangitis (PBC) Phase 2 Phase 2 top-line data released late May 2016. Second trial to be initiated by end of 2016
$1.68
-0.02  -1.15%
$18.46M
10,987,000
7.95
08/15/2016
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Drug Indication Stage News
CBLB612 - Russia trial Breast cancer Phase 2 Phase 2 ongoing
Entolimod - Russia trial Neo-adjuvant therapy in treatment-naïve patients with primary colorectal cancer Phase 2 Phase 2 being prepared for analysis
$0.48
-0.02  -4.1%
$12.59M
26,335,000
0.39
07/25/2016
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Drug Indication Stage News
Hydros-TA Osteoarthritis of the knee Phase 3 Not pursuing further development
$5.25
+0.04  +0.77%
$250.75M
47,762,000
10.69
09/01/2016
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Drug Indication Stage News
CCX140 Diabetic nephropathy Phase 2 Phase 2 topline data released Dec 12 2014. End of Phase 2 meeting planned with FDA
CCX168 Atypical Hemolytic Uremic Syndrome (aHUS) Phase 2 Phase 2 data due 2016
CCX168 Associated vasculitis (AAV) Phase 2 Phase 3 to be initiated by the end of 2016.
CCX872 Non-resectable pancreatic cancer Phase 1b Phase 1b early response data released September 1, 2016. Initial PFS data due by the end of 2016
Vercirnon CCX282 Crohn’s disease Phase 3 Partner required to continue with Phase 3 program
$11.67
-0.48  -3.95%
$162.28M
13,906,000
10.08
08/13/2016
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Drug Indication Stage News
CD101 IV - STRIVE Candidemia Phase 2 Phase 2 initiated June 2016
CD101 Topical - RADIANT Vulvovaginal candidiasis (VVC) Phase 2 Phase 2 initiated June 2016
$24.72
-0.49  -1.94%
$1.29B
51,991,000
9.49
08/30/2016
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Drug Indication Stage News
CEM-101 (solithromycin ) Uncomplicated urogenital gonococcal infections Phase 3 Phase 3 initiated August 2014. Enrolment completed December 2015 but decided to increase enrolment. Ongoing as of August 2016
Solithera - intravenous Community-acquired bacterial pneumonia (CABP) PDUFA PDUFA December 28 2016. Antimicrobial Drugs Advisory Committee scheduled for November 4, 2016
Solithera - oral Community-acquired bacterial pneumonia (CABP) PDUFA PDUFA December 27 2016. Antimicrobial Drugs Advisory Committee scheduled for November 4, 2016
Solithromycin NASH Phase 2 Phase 2 interim data due 4Q 2016
Solithromycin COPD Phase 2 Phase 2 ongoing as of August 2016
Taksta Acute bacterial skin and skin structure infections (ABSSSI) Phase 3 Phase 3 initiated December 2015. Trial to be completed 1H 2017
$4.76
-0.15  -2.96%
$41.17M
8,650,000
1.94
09/21/2016
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Drug Indication Stage News
CERC-301 Major depressive disorder (MDD) Phase 2 Phase 2 top-line data due November 2016.
CERC-501 Smoking cessation Phase 2 Phase 2 top-line data due December, 2016.
$6.30
+0.07  +1.12%
$647.07M
102,709,000
11.49
07/25/2016
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Drug Indication Stage News
INTERCEPT Platelets Approved PMA approved Dec 18 2014
INTERCEPT B123 Plasma Approved PMA approved Dec 16 2014
$1.06
+0.11  +11.58%
$29.03M
27,384,000
0.39
08/18/2016
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Drug Indication Stage News
CRLX101 and Avastin - RCC Trial 3rd and 4th line Relapsed Renal Cell Carcinoma cancer Phase 2 Phase 2 data released August 2016 failed to meet primary endpoint
CRLX101 and paclitaxel Platinum-resistant ovarian cancer Phase 2 Further interim data due at the 2016 European Society for Medical Oncology (ESMO) Congress 7-11 October 2016
CRLX101 in Combination with Chemotherapy and Radiation Renal Cell Carcinoma cancer Phase 2 Initial data released mid March 2015. Further interim data due 2H 2016
CRLX101, in combination with LYNPARZA Solid tumors - cancer Phase 1/2 Phase 1/2 trial commenced dosing May 2016. Top-line data due 1H 2017
$2.29
-0.03  -1.29%
$95.12M
41,539,000
4.28
08/15/2016
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Drug Indication Stage News
CF-301 Serious infections caused byStaph aureus including MRSA Phase 2 Phase 2 to be initiated 4Q 2016 with data due 2Q 2018
$3.05
+0.21  +7.39%
$74.29M
24,356,000
16.25
08/15/2016
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Drug Indication Stage News
Mycapssa Acromegaly CRL CRL April 15 2016
Mycapssa Neuroendocrine tumors (NET) Phase 2 Phase 2 planned
Oral octreotide Neuroendocrine tumors (NET) Phase 2 Phase 2 to be initiated late 2016
$29.69
-0.31  -1.03%
$1.29B
43,380,000
11.63
08/13/2016
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Drug Indication Stage News
CHS-0214 Psoriasis Phase 3 Phase 3 trial met endpoint November 2015. However, commercialization not possible in US before 2029 due to patent issues
CHS-131 Relapsing remitting multiple sclerosis (RRMS) Phase 2b Phase 2b data released June 2016
CHS-1420 Psoriasis Phase 3 Phase 3 top-line data met endpoints August 2016. Full data due 4Q 2016 with BLA filing to follow.
CHS-1701 Pegfilgrastim biosimilar BLA Filing BLA filed August 9 2016
$4.64
-0.24  -4.92%
$N/A
0
0.00
09/06/2016
Tap to view 2 drugs
$32.48
+1.12  +3.57%
$498.05M
15,334,000
0.83
09/06/2016
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Drug Indication Stage News
Lasmiditan - SAMURAI Migraine Phase 3 Phase 3 top-line data met endpoints - September 6, 2016
Lasmiditan - SPARTAN Migraine Phase 3 Phase 3 top-line data 2H 2017
$3.80
-0.03  -0.78%
$382.07M
100,545,000
8.95
08/15/2016
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Drug Indication Stage News
CDX-014 Renal cell carcinoma (RCC) - cancer Phase 1/2 Phase 1/2 initiated July 2016
CDX-110 (rindopepimut) in combination with Avastin - ReACT Glioblastoma multiforme (GBM) refractory cancer Phase 2 Phase 2 endpoint met - ASCO 2015
CDX-110 rindopepimut - ACT IV Cancer- glioblastoma multiforme (GBM) front line Phase 3 Trial discontinued early March 2016 as unlikely to meet primary endpoint
Glembatumumab vedotin Squamous cell lung cancer Phase 1/2 Phase 1/2 commenced April 2016
Glembatumumab vedotin Metastatic triple negative breast cancers that overexpress gpNMB Phase 2a Phase 2b enrolment to be completed by end of 2016
Glembatumumab vedotin Cancer - melanoma Phase 2 Phase 2 initiated December 2014. Data to be at the European Society for Medical Oncology (ESMO) Congress in October 2016
Varlilumab and atezolizumab (anti-PDL1) Renal cell carcinoma (RCC) cancer Phase 1/2 Phase 2 part of trial to be initiated 3Q 2016
Varlilumab and nivolumab Solid tumors - cancer Phase 2 Phase 2 initiated April 2016
Varlilumab and sunitinib (Sutent) Clear cell renal cell carcinoma (CC-RCC) cancer Phase 1/2 Enrolling
$2.66
-0.08  -2.92%
$14.28M
5,368,000
2.15
09/08/2016
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Drug Indication Stage News
CLR 131 Phase 2 Phase 2 trial to be initiated 1H 2017
$15.26
+1.28  +9.16%
$313.52M
20,545,000
1.74
08/03/2016
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Drug Indication Stage News
CLS-1001 Macular edema associated with non-infectious uveitis Phase 3 Phase 3 data due 2H 2017
CLS-1002 Wet age-related macular degeneration (Wet-AMD) Phase 1/2 Phase 1/2 trial to be initiated following IND submission 2H 2016
Zuprata - CLS-1003 Macular edema associated with retinal vein occlusion (RVO) Phase 2 End of Phase 2 meeting planned for 2H 2016. Phase 3 trial to commence 1H 2017 pending positive outcome from meeting
$1.24
-0.02  -1.59%
$32.00M
25,810,000
4.70
09/15/2016
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Drug Indication Stage News
GEN-1 OVATION Ovarian cancer Phase 1b Phase 1b data due 1Q 2017
ThermoDox Hepatocellular carcinoma - liver cancer Phase 3 Failed to meet primary endpoint. New Phase 3 enrolment to be completed late 2017 or early 2018
ThermoDox - Dignity Recurrent Chest Wall Breast Cancer (RCWBC) Phase 2 Final data released December 2015
$36.82
-0.32  -0.86%
$1.42B
38,501,000
3.52
09/08/2016
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Drug Indication Stage News
Lucitanib Breast cancer Phase 2 Development discontinued
Rociletinib Mutant EGFR T790M-positive lung cancer CRL PDUFA date was June 28, 2016. Company expect CRL. Phase 3 TIGER-3 also terminated
Rociletinib in combination with atezolizumab EGFR-mutant non-small cell lung cancer Phase 1b Phase 1b/2 trial initiated January 2016
Rucaparib ARIEL2 Cancer - ovarian second line PDUFA priority review PDUFA under priority review February 23, 2017. No Advisory Committee meeting required
Rucaparib ARIEL3 Ovarian cancer patients with a BRCA-like mutation Phase 3 Pivotal trial initiated late 2013. Enrolment completed 2Q 2016. Data due 4Q 2017
$5.60
-0.12  -2.1%
$258.80M
46,214,000
7.40
07/25/2016
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Drug Indication Stage News
Brincidofovir - Advise trial Adenovirus Infection Phase 3 Phase 3 interim analysis released May 2016
Brincidofovir - SUPPRESS Cytomegalovirus (CMV) infection following an allogeneic hematopoietic stem cell transplant (HSCT) Phase 3 Phase 3 endpoints not met December 2015
Brincidofovir - SURPASS Cytomegalovirus (CMV) infection Phase 3 Phase 3 discontinued following poor data from SUPPRESS trial
Brincidofovir - SUSTAIN Cytomegalovirus (CMV) infection Phase 3 Phase 3 discontinued following poor data from SUPPRESS trial
$2.10
-0.01  -0.47%
$46.35M
22,072,000
0.76
08/04/2016
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Drug Indication Stage News
Emricasan Acute-on-Chronic Liver Failure (ACLF) Phase 2 Phase 2 topline data released Jan 2015
Emricasan Portal Hypertension Phase 2 Phase 2 data released September 2015.
Emricasan Liver fibrosis post-orthotopic liver transplant due to Hepatitis C virus infection (HCV-POLT) Phase 2a Phase 2b initiated May 2014. Topline data due 1H 2018
Emricasan NASH fibrosis - ENCORE-NF trial Phase 2 Phase 2 trial initiated January 2016. Data are due 2018
Emricasan Liver Cirrhosis Phase 2 Phase 2 topline data released early January 2016
$10.31
+0.16  +1.58%
$229.16M
22,227,000
3.75
08/15/2016
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Drug Indication Stage News
AVP-786 Major depressive disorder Phase 2
AVP-786 Agitation in patients with Alzheimer’s disease Phase 3 Phase 3 initiated December 2015. Trial to be completed 3Q 2018
CTP-499 Diabetic Kidney Disease Phase 2 Phase 3 planned. Needs partner
CTP-656 Cystic fibrosis Phase 2 Phase 2 planned for 2H 2016
$15.82
+0.34  +2.2%
$372.21M
23,528,000
10.04
08/13/2016
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Xtampza ER (oxycodone) Severe pain Approved Approved April 26 2016
$6.50
+0.01  +0.15%
$718.86M
110,594,000
21.50
08/15/2016
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CORT125134 Solid tumors - cancer Phase 2 Phase 2 initiated 1Q 2016
CORT125134 Cushing’s syndrome Phase 2 Phase 2 trial initiated 2Q 2016
Mifepristone in combination with eribulin Cancer - triple-negative breast cancer Phase 1/2 Phase 1/2 data due 3Q 2017
Mifepristone plus Abraxane Triple-negative breast cancer Phase 2 Phase 2 planned
Mifepristone plus enzalutamide Castration-resistant prostate cancer (CRPC) Phase 2 Phase 2 enrolling
$1.17
-0.08  -6.4%
$96.96M
82,870,000
1.98
09/02/2016
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Firdapse MuSK-antibody positive myasthenia gravis (MuSK-MG) Phase 2/3 Phase 2/3 top-line data due early 2017
Firdapse Congenital Myasthenic Syndromes (CMS) Phase 3 Phase 3 data due 2H 2017
Firdapse Lambert-Easton Myasthenic Syndrome (LEMS) Phase 3 Refusal to file letter reported on Feb 17 2016 for Dec 2015 NDA Filing. Additional Phase 3 trial planned for 4Q 2016. Data due 2H 2017
$6.37
+0.12  +1.92%
$278.67M
43,748,000
0.39
09/14/2016
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Resunab Cystic Fibrosis Phase 2 Phase 2 data due early 1Q 2017. February 15, 2017 listed in the FDA Calendar as last possible date assuming company guidance of ‘EARLY 1Q’ 2017
Resunab Systemic lupus erythematosus (SLE) Phase 2 Phase 2 trial to be initiated 1H 2017
Resunab Dermatomyositis Phase 2 Phase 2 to complete enrollment 2Q 2017
Resunab Systemic Sclerosis Phase 2 Phase 2 data due 4Q 2016
$2.43
-0.05  -2.02%
$314.62M
129,472,000
16.37
08/05/2016
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CUDC-907 Diffuse-large B-cell lymphoma (DLBCL) Phase 2 Phase 2 data due 2017
$2.72
-0.04  -1.45%
$101.15M
37,187,000
10.11
08/15/2016
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Drug Indication Stage News
Neutrolin - LOCK-IT 100 Hemodialysis patients with central venous catheters Phase 3 Phase 3 enrolment to be completed in 2016. Interim analysis due 4Q 2016 with Phase 3 data due 3Q 2017
Neutrolin - LOCK-IT 200 Oncology patients on Total Parental Nutrition (TPN) Phase 3 Phase 3 to be initiated pending funding
$15.92
+0.08  +0.51%
$332.87M
20,909,000
16.41
08/15/2016
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CPI-444 Solid tumors - cancer Phase 1b Phase 1/1b enrolling
$0.38
-0.01  -0.52%
$107.09M
279,604,000
0.96
08/29/2016
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Drug Indication Stage News
OPAXIO Ovarian cancer Phase 3 Phase 3 - noted July 2016 that unlikely to have survival benefit
Pacritinib Myelofibrosis Phase 3 PERSIST-2 data released August 2016. One of two primary endpoints met. Previously placed on clinical hold in February 2016
Tosedostat Older patients with AML or high-risk myelodysplastic syndrome (MDS) - cancer Phase 2 Phase 3 trial potentially starting in 2016, depending on discussions with FDA
$1.28
-0.02  -1.92%
$159.50M
124,608,000
0.00
08/15/2016
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Drug Indication Stage News
Brilacidin Oral mucositis Phase 2 Phase 2 ongoing
Brilacidin Ulcerative proctitis Phase 2 Phase 2 ongoing
Brilacidin Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Phase 2 Phase 3 planned
Cellceutix Placque psoriasis Phase 2 Phase 2b trial to be initiated late 3Q or early 4Q 2016. Data due 2Q 2017
Kevetrin Ovarian cancer Phase 2 Phase 2 to commence 4Q 2016
$1.11
-0.06  -5.13%
$35.78M
32,231,000
6.57
08/15/2016
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