Price and Volume Movers
Aviragen Therapeutics (NASDAQ:AVIR) announced back-to-back trial failures when it announced today that top-line data from its Phase 2b SPIRITUS trial, in moderate to severe asthmatics with a rhinovirus (RV) infection, did not meet the primary endpoint. Shares have slumped 45% to $0.59 in the after hours session.
Shares of Zosano Pharma Corporation (NASDAQ:ZSAN) soared in the morning session following its announcement that it achieved both co-primary endpoints of pain freedom and most bothersome symptom freedom at 2 hours in its Phase 3 trial of M207 for the treatment of migraine. M207 was not associated with any Serious Adverse Events (SAEs). Shares of the nano-cap company closed up 42% to $1.70 on its session lows after being up over 100% earlier in morning trading.
Sage Therapeutics (NASDAQ:SAGE) announced top-line data from its Phase 2 trial of SAGE-217 for the treatment of major depressive disorder (MDD), an open-label 13 patient trial. The trial measured the effect of SAGE-217 on the Hamilton Rating Scale for Depression (HAM-D) total score. 85% (11 of 13) of patients exhibited at least a 50% reduction of their HAM-D and 62% (8 of 13) of patients achieving remission. The company will now proceed to the double-blind, placebo-controlled part of the Phase 2 trial. Investors reacted positively to the data, sending shares higher to close up 12% to $52.99.
Axovant Sciences (NYSE: AXON) announced preliminary results from the first 11 patients in its Phase 2 study of nelotanserin in Lewy body dementia patients. It achieved the primary endpoints of the trial. However, secondary endpoints were not met. The news sent shares lower, closing down 6% to $11.85. Axovant expects the full study to complete in mid-2017 and plans to present detailed results at a scientific meeting in 2017. It expects to initiate a Phase 3 program in 2H 2017.
Allergan plc (NYSE:AGN) announced that it will acquire ZELTIQ Aesthetics, Inc. (NASDAQ:ZLTQ), a medical technology company, for $56.50 per share, or $2.475b.
XOMA Corporation (Nasdaq:XOMA) announced that it will issue 1.2m shares and 5,003 shares of convertible preferred stock in a registered direct offering for gross proceeds of approximately $25m. Shares traded higher, closing up 20% to $4.82.
Other major price movers:
Rexahn Pharmaceuticals, Inc. (NYSEMKT:RNN): $0.285; +40%.
Protalix Biotherapeutics Inc (NYSEMKT:PLX): $1.31; +30%
Navidea Biopharmaceuticals Inc (NYSEMKT:NAVB): $0.43; +25%.
Cerulean Pharma Inc (NASDAQ:CERU): $1.54; +18%.
Aurinia Pharmaceuticals Inc (NASDAQ:AUPH): $3.62; +12%.
Celsion Corporation (NASDAQ:CLSN): $0.388; -14%.
Dipexium Pharmaceuticals Inc (NASDAQ:DPRX): $1.20; -11%.
Cara Therapeutics Inc (NASDAQ:CARA): $13.51; -9%.
Chiasma Inc (NASDAQ:CHMA): $1.70; -8%.
Pulmatrix Inc (NASDAQ:PULM): $4.34; -7%.
Full pipeline updates below: